Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
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Year : 1991  |  Volume : 36  |  Issue : 2  |  Page : 21-27

Double-blind comparison of mometasone furoate 0.1 percent and betamethasone valerate 0.12 percent creams in dermatoses

Department of Dermatology & STD National Medical College & Hospital, Calcutta

Correspondence Address:
SK Panja
Department of Dermatology & STD National Medical College & Hospital, Calcutta

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Source of Support: None, Conflict of Interest: None

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ABSTRACT: The efficacy and safety of mometasone furoate 0.1 percent cream, a formulation of a new non-fluorinated topical steroid, were evaluated in comparison with those of betamethasone valerate 0.12 percent cream. Both creams were applied twice-daily for 21 days in this randomised, double-blind, parallel- group clinical study. One hundred thirty-five patients (68 plus 67) of moderate to severe dermatoses completed the study. Three cardinal signs (erythema, induration, pruritus) together with physician's global evaluation during each weekly follow-up were the criteria of efficacy. Both drugs were efficacious in treating dermatoses. However, mometasone furoate was significantly more effective as compared to betamethasone valerate. Only one patient in each treatment group showed an adverse drug effect.

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