Indian Journal of Dermatology
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Year : 1992  |  Volume : 37  |  Issue : 4  |  Page : 35-41

In vitro susceptibility of dermatophytes to imidazoles

Institute of Microbiology, Madurai College, Madurai and Madras Medical College Madras, India

Correspondence Address:
PV Venugopal
Institute of Microbiology, Madurai College, Madurai and Madras Medical College Madras
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Source of Support: None, Conflict of Interest: None

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ABSTRACT: In vitro susceptibility testing of 88 clinical isolates of dermatophytes comprising of Microsporum canis (50), M. audouinii (5) Trichophyton rubrum (6), T. mentagrophytes (5), T. violaceum (12), T, simii (5), T. verrucosum (1), T.soudanense (1), T erinacei and Epidermophyton floccosum (2) were carried out against imidazoles - Ketoconazole, miconazole and econazole by agar dilution method. The inhibitory activities of these agents were compared with that of griseofulvin. Econazole was found to be most active, inhibiting all the isolates at a concentration of 0.1 ug/ml. (minimal inhibitory concentration - MIC range 0.001 - 0.1 ug/ml). Ninety percent of the isolates tested were inhibited by 2.5 ug/ml of ketoconazole (MIC range 0.1-5 ug/ml) and miconazole (MIC range 0.1- 5 ug/ml) each where - as 5 ug/ml of griseofulvin (MIC range 0.1-5 ug/ml) was required for the same.)

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