PV Venugopal Institute of Microbiology, Madurai Medical College, Madurai
Source of Support: None, Conflict of Interest: None
ABSTRACT: In vitro susceptibility testing of 43 clinical isolates of dermatophytes was carried out against itraconazole by agar dilution and disk diffusion methods. The results were compared with that of ketoconazole. Itraconazole was more active, inhibiting 90 percent of the isolates (MIC 90) at a concentration of 0.5 ug/ml (MIC range 0.01-5 ug/ml) required 1 and 2.5 ug/ml for inhibiting 50 and 90 percent of the isolates. The MIC values and the sizes of zones of inhibition correlated well for both the drugs. Regression analysis was used to measure the degree of correlation between the MIC values and matched averaged zones of inhibition and the correlation coefficients for itraconazole and ketoconazole were - 0.4225 (P0.01) and - 0.5886 (P0.001) respectively.