Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
Indexed with Science Citation Index (E) , Web of Science and PubMed
Users online: 3843  
Home About  Editorial Board  Current Issue Archives Online Early Coming Soon Guidelines Subscriptions  e-Alerts    Login  
    Small font sizeDefault font sizeIncrease font size Print this page Email this page
Year : 1994  |  Volume : 39  |  Issue : 2  |  Page : 19-21

A new intralesional therapy of cutaneous leishmaniasis with hypertonic sodium chloride solution.

Department of Dermatology, College of Medicine, University of Baghdad, Bab-Al Moadham, P.O. Box 14321, Baghdad, Iraq

Correspondence Address:
KE Sharquie
Department of Dermatology, College of Medicine, University of Baghdad, Bab-Al Moadham, P.O. Box 14321, Baghdad
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

ABSTRACT: One hundred and fifty eight lesions of acute cutaneous leishmaniasis in 70 patients were treated with hypertonic sodium chloride solution (88 lesions), pentostam (50 lesions) and 20 lesions were left untreated as controls. The injections were given at 7-10 day intervals and patients were followed-up for 42 days. Hypertonic sodium chloride solution was shown to be very effective local therapy (96 percent cure rate) and was as effective as local pentostam (96.4 percent cure rate). In both types of therapy most lesions needed one injection. Mild improvement was noticed after 7-10 days of the first injection while the cure was noticed within 2-6 weeks (mean 4 weeks) of follow up. None of the control lesions showed a cure within the 6 weeks follow-up. The mechanism of action of both local hypertonic sodium chloride and sodium stibogluconate (pentostam) is probably through interfering with osmotic pressure of cell cytoplasm of the parasites and the lesional tissues. Scarring was either absent or minimal following healing of the treated lesions in both types of treatment. Post-inflammatory hyperpigmentation was observed in all patients. We strongly recommend intralesional hypertonic sodium chloride as a cheap, safe, and effective method of treating cutaneous leishmaniasis.

[PDF Not available]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal