Source of Support: None, Conflict of Interest: None
Check
Fifty consecutive patients of dermatophytosis satisfying a set of inclusion/exclusion criteria randomly received treatment with either 1% or 2% clotrimazole gel in a double blind set up of 42 patients who completed the study. 20 received treatment with 1% (Gr. 1) and 22 with 2% (Gr. 2) clotrimazole gel. Trichophyton rubrum was grown in culture from lesions of all patients. No statistically significant difference was found in clinical scores and mycologic findings at the beginning of study and after first week of treatment. At the end of second week, Gr. 2 showed statistically significant reduction in the seventy of clinical illness and mycologic clearance in a significantly larger number of cases compared to Gr. 1. At the end of 4 week study, however, no significant difference in the overall cure rates – 81.8% in Gr. 2 and 80% in Gr. 1 – was observed. It was concluded that compared to 1% formulation, clotrimazole as a 2% gel provides faster mycologic clearance and earlier clinical improvement in dermatophytosis.
