Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
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Year : 2004  |  Volume : 49  |  Issue : 3  |  Page : 154-155

Leflunomide Induced Drug Rash And Hepatotoxicity

Correspondence Address:
Monica Uppal

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Source of Support: None, Conflict of Interest: None

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A 57 year old female presented with generalized erythematous scay plaques of 11/2 months duration and jaundice since 1 month. She was on leflunomide since 3 months for chronic rheumatoid arthritis. Investigations revealed positive ANA, rheumatoid factor and negative anti-DsDNA. Bilirubin and liver enzymes were markedly raised. Viral markers were negative. Direct immunoflourescence did not show lupus band. A diagnosis of drug induced hepatitis and skin rash was made. She was treated with cholestyramine but she died after ten days of hospitalization.

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