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| Year : 2005 | Volume
: 50
| Issue : 1 | Page : 9-16 |
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Effect Of Prologned Low-Dose Oral Asirin On The Oxidative Status Of Peripheral Blood Mononuclear Cells Of Active Vitiligo
Mohammad Z A Zailaie
Correspondence Address:
Mohammad Z A Zailaie
 Source of Support: None, Conflict of Interest: None  | Check |
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There is a growing body of evidence that the etiology of vitiligo may relate primarily to an imbalance in the oxidative status the epidermal melanocytes and other cells that include peripheral blood mononuclear cells (PBCM). Consequently, this pilot placebo-controlled study was designed to evaluate the effect of long-term (12 weeks) oral administration of single low-dose (300mg) of the nonsteroidal anti-inflammatory drug, aspirin on the antioxidant enzymes (catalase, glutathione peroxides (GPx), and superoxide dismutase (SOD)) activities and the intracellular levels of reduced glutathione (GSH) and lipid peroxidation of PBCM in patients with vitiligo in the active phase. Thirty two adult patients with active vitiligo (18 females and 14 males) and 32 normal healthy age-and sex-matched subjects were recruited. The vitiligo patients were divided into two equal groups; one group received a single daily dose of oral aspirin and the other one received placebo for 12 consecutive weeks. The antioxidant enzymes, GSH and the marker of lipid peroxidation, malonidaldehyde (MDA) were determined in the supernatant of PBCM homogenates of vitiligo patients (aspirin-treated and placebo groups) before the start of treatment and at the end of treatment period. The determination of these cell markers was carried out with the use of commercially available kits, according to standardized spectrophotometric methods. Compared with the placebo group, the aspirin-treated group of vitiligo patients showed significant increases in catalase and GPx activities (p<0.001 and p<0.05 respectively) and a significant decrease in MDA concentration (p<0.05). Parallel to these changes there was a considerable improvement in the disease activity in all aspirin- treated patients, as well significant repigmentation in two at the end of the study period. |
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