Indian Journal of Dermatology
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Year : 2007  |  Volume : 52  |  Issue : 4  |  Page : 204-205

Centrifugal necrotic keratoacanthoma

Department of Dermatology, University of Palermo, Palermo, Italy

Correspondence Address:
Valentina Caputo
Viale Strasburgo 440, 90146, Palermo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-5154.37729

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Centrifugal necrotic keratoacanthoma is a quite rare variant of keratoacanthoma, with a locally aggressive behavior and no tendency to spontaneous involution. We report a typical case of the nasal-orbital region. Based on its clinical, histological and behavioral picture, centrifugal necrotic keratoacanthoma appears as variant of giant keratoacanthoma and can be regarded as an intermediate form in a spectrum where keratoacanthoma and overt squamous cell carcinoma represent the most benign and the most malignant end, respectively, as also highlighted by analogies between the two lesions recently reported in the field of molecular biology.

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