Indian Journal of Dermatology
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Year : 2018  |  Volume : 63  |  Issue : 5  |  Page : 386-390

Pathogenic yeasts recovered from acne vulgaris: Molecular characterization and antifungal susceptibility pattern

1 Department of Medical Mycology, Faculty of Medicine, Islamic Azad University, Tonekabon, Iran
2 Department of Dermatology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran

Correspondence Address:
Dr. Ayatollah Nasrollahi Omran
Department of Medical Mycology, Faculty of Medicine, Tonekabon Branch, Islamic Azad University, Tonekabon
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijd.IJD_351_17

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Context: Acne vulgaris is a disorder showing persistent inflammation in the pilosebaceous follicles. It is one of the most prevalent dermatoses that millions of people suffer from globally. Aim: The aim of this study was to identify Candida species from patients with acne and to determine their drugs susceptibility. Subjects and Methods: A total of 70 cutaneous samples from acne vulgaris patients suspected to have Candida infections were collected. Macroscopic and microscopic morphology were recorded followed by polymerase chain reaction-sequencing of ITS regions, using universal primers. In vitro antifungal susceptibility was performed using Clinical and Laboratory Standards Institute method. Results: Overall, 11 Candida species including Candida parapsilosis 8 (72.73%), Candida krusei 1 (12.5%), Candida lusitaniae 1 (12.5%), Candida kefyr 1 (12.5%), and a Trichosporon asahi out of the collected clinical materials were isolated and identified. C. parapsilosis isolates susceptibility to diverse concentrations of the antifungal agents to isolate Cp1 study indicated that the isolated Cp8 and Cp5 with minimal inhibitory concentration (MIC) 50 = 32, 0.5, 0.25 and MIC 90 of <64, <1, <0.5 μg/ml fluconazole, itraconazole, and ketoconazole were resistant, respectively. Some of the isolates having relative strength, almost all other species of C. parapsilosis isolates were susceptible to these drugs. Conclusion: C. parapsilosis was the most prevalent Candida species in acne vulgaris samples which had higher in vitro susceptibility for antifungals.

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