Systemic redox imbalance along with increased serum sialic acid is prevalent in patients with active vitiligo: A study from a tertiary care teaching hospital of eastern India

Nilotpal Banerjee; Sanchaita Gayen; Dolanchampa Modak; Somenath Sarkar; Bibhuti Saha; Sumi Mukhopadhyay

doi:10.4103/ijd.IJD_448_17

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ORIGINAL ARTICLE

Year : 2019 | Volume : 64 | Issue : 2 | Page : 97-100

Systemic redox imbalance along with increased serum sialic acid is prevalent in patients with active vitiligo: A study from a tertiary care teaching hospital of eastern India

Nilotpal Banerjee¹, Sanchaita Gayen¹, Dolanchampa Modak², Somenath Sarkar³, Bibhuti Saha², Sumi Mukhopadhyay¹
¹ Department of Laboratory Medicine, Calcutta School of Tropical Medicine, Government of West Bengal, Kolkata, West Bengal, India
² Department of Tropical Medicine, Calcutta School of Tropical Medicine, Government of West Bengal, Kolkata, West Bengal, India
³ Department of Dermatology, Bankura Sammilani Medical College, Government of West Bengal, Bankura, West Bengal, India

Correspondence Address:
Dr. Sumi Mukhopadhyay
Department of Laboratory Medicine, Calcutta School of Tropical Medicine, Government of West Bengal, 108, Chittaranjan Avenue, Kolkata - 700 073, West Bengal
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/ijd.IJD_448_17

Background: Vitiligo is one of the common depigmenting disorders causing disfigurement and affecting the quality of life. Redox imbalance is known to play a contributory role in melanocyte destruction. Serum sialic acid (SA) is an important marker of the acute-phase response and is associated with oxidative protein damage. Aim: The aim of this study was to analyze the status of oxidative stress markers and serum SA in vitiligo patients and to correlate the same with disease activity. Materials and Methods: The different oxidative stress parameters namely superoxide dismutase (SOD), malondialdehyde (MDA), and serum SA were measured spectrophotometrically using standard biochemical methodologies in all the study subjects. Results: Serum SOD and MDA values were higher in patients with active vitiligo (n = 23) as compared to stable vitiligo (n = 20) and healthy controls (n = 20). The MDA/SOD ratio was higher in patients with active vitiligo (P<0.0001). Serum SA was increased in active vitiligo as compared to stable vitiligo and healthy controls (P<0.0001). Conclusion: This study indicates that patients with active vitiligo demonstrate enhanced MDA/SOD ratio and increased serum SA. The studied parameters can serve as an important tool to monitor disease activity in vitiligo.

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