Indian Journal of Dermatology
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Year : 2019  |  Volume : 64  |  Issue : 3  |  Page : 231-234

MORFAN syndrome: A rarity but a reality!

Department of Dermatology, Institute of Post Graduate Medical Education and Research and SSKM Hospital, Bhowanipore, Kolkata, West Bengal, India

Correspondence Address:
Dr. Shreya Poddar
Flat No. 202, Rukmani Apartments, Near Chowk Thana, Jhauganj, Patna - 800 008, Bihar
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijd.IJD_160_19

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Acanthosis nigricans (AN) describes clinically hyperpigmented skin, which most commonly affects the flexural areas such as axilla, groin and neck. It is usually a benign condition associated with obesity, insulin resistance, and hyperinsulinemia; endocrinopathy; or malignancy, in particular, gastrointestinal adenocarcinoma. It can also occur in association with various genetic syndromes involving various organ systems. Few such known syndromes are Berardinelli-Seip syndrome, Alström syndrome, Leprechaunism, and Bardet-Biedl syndrome. MORFAN syndrome, which associates mild mental retardation, pre- and post-natal overgrowth, remarkable facies and diffuse and widespread AN, is a rare entity.

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