Indian Journal of Dermatology
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  Official organ of AADV
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Year : 2019  |  Volume : 64  |  Issue : 3  |  Page : 239-241

Apremilast coadministered with secukinumab for safe and effective control of psoriasis with resultant reduction of maintenance dose of the biologic

1 Department of Dermatology, Calcutta National Medical College, Kolkata, West Bengal, India
2 Medical Services, Glenmark Pharmaceuticals Ltd, Mumbai, Maharashtra, India
3 Department of Dermatology, Wizderm Skin and Hair Clinic, Kolkata, West Bengal, India

Correspondence Address:
Dr. Dhiraj Dhoot
B D Sawant Marg, Chakala, Andheri (E), Mumbai, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijd.IJD_548_18

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Psoriasis is a chronic immune-mediated inflammatory condition, affecting 2–3% of the population. In recent years, advent of biologics, including secukinumab, have been a major advancement in the management of difficult-to-treat plaque psoriasis. However, high cost of biologics is often a deterrent, especially for Indian socioeconomic condition. Apremilast is an oral phosphodiesterase 4 inhibitor that is safe for use along with many other systemic therapies of psoriasis, including biologics. We report two cases of psoriasis on secukinumab therapy for long duration with good response to therapy. Later, addition of apremilast, allowed halving the dose of secukinumab with maintenance of improvement.

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