| REVIEW ARTICLE |
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| Year : 2022 | Volume
: 67
| Issue : 1 | Page : 31-36 |
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Correlation between Serum 25-Hydroxy Vitamin D levels and the severity of acne vulgaris: A systematic review
Shinta D Rasti, Nena R Dewinta, Ronik H Kamal, Avina F Adissadah, Afhama E Madanny, Linda Dewanti
Department of Public Health and Preventive Medicine, Faculty of Medicine, Airlangga University, Kota SBY, Jawa Timur, Indonesia
Correspondence Address:
Linda Dewanti
Department of Public Health and Preventive Medicine, Faculty of Medicine, Airlangga University, Prof. Dr. Moestopo Street No. 47, Surabaya, East Java - 60132
Indonesia
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijd.ijd_871_21
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Background: Vitamin D is thought to play a role in the pathogenesis of acne, and its levels can change in patients with acne vulgaris. Several studies have revealed that serum 25-hydroxy vitamin D levels tend to be low and statistically significant in acne vulgaris patients. However, the relationship between vitamin D levels and acne severity is still poorly understood. Objective: This study aims to identify the correlation between serum 25-hydroxy vitamin D levels and the severity of acne vulgaris. Method: This systematic review study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline based on several studies taken from the PubMed, PMC, Semantic Scholar, and ResearchGate databases until June 2021. Full-text case-control, randomized controlled trial, or cross-sectional study in English or Indonesian language reporting on the serum 25-hydroxy vitamin D levels and the severity of acne vulgaris on human participants were included. Result: From a total of 401 studies, 10 studies met the criteria. Almost all studies (8 of 10) revealed lower serum 25-hydroxy vitamin D levels as the acne severity progresses, although 2 of them were not statistically significant. Conclusion: The evidence of an inverse correlation between serum 25-hydroxy vitamin D levels and the severity of acne vulgaris suggests the need for screening of vitamin D levels in acne patients and offers a new prospect in the field of acne prevention and treatment.
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