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Year : 2022  |  Volume : 67  |  Issue : 1  |  Page : 95
Non-ulcerative variant of erythema induratum of bazin in an Indian female

1 Department of Dermatology, Lady Hardinge Medical College, New Delhi, India
2 Department of Pathology, Lady Hardinge Medical College, New Delhi, India

Date of Web Publication19-Apr-2022

Correspondence Address:
Deepika Yadav
Department of Dermatology, Lady Hardinge Medical College, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijd.ijd_362_21

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How to cite this article:
Mendiratta V, Yadav D, Senapati D, Agarwal S. Non-ulcerative variant of erythema induratum of bazin in an Indian female. Indian J Dermatol 2022;67:95

How to cite this URL:
Mendiratta V, Yadav D, Senapati D, Agarwal S. Non-ulcerative variant of erythema induratum of bazin in an Indian female. Indian J Dermatol [serial online] 2022 [cited 2023 Jun 4];67:95. Available from:


Erythema induratum of Bazin (EIB) is a chronic recurrent disease characterized by erythematous plaques and subcutaneous nodules, which usually ulcerate, affecting the lower legs of adult women.[1] EIB is a rare entity among cutaneous tuberculosis and in an Indian study, EIB accounted for 1.5% of the total cases of cutaneous tuberculosis.[2]

We present a case of a middle-aged female with atypical features, including annular plaques and non-ulcerative nodules, diagnosed as EIB.

A 58-year-old hypertensive and diabetic female presented with a 10-month history of a single, erythematous, and depressed plaque over the right lower leg. There was history of multiple, painful, red raised lesions over the anterior aspect of the right leg since 3 weeks. There was no history of trauma, radiation exposure, vaccination, loss of weight, fever, cough, and family or personal history of tuberculosis. On examination, there was a 3 cm × 4 cm ill-defined, erythematous, indurated, tender plaque on the anteromedial aspect of the right lower leg [Figure 1]. Multiple well-defined erythematous annular plaques were present over the anterior aspect of the right leg [Figure 1]. Two violaceous, tender 1 cm × 1 cm nodules were present on right calf. There was no ulceration or pus discharge. Systemic examination did not reveal any abnormality. BCG scar was noted on left upper arm.
Figure 1: One single indurated plaque (blue arrow) and multiple erythematous annular plaques (black arrows) on anteromedial aspect of right leg. Inset on right side showing follow-up image after 1 week (resolution of annular plaques)

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A clinical differential diagnosis of deep morphea, necrobiosis lipoidica, and erythema induratum was considered. Blood investigations revealed mild anemia, elevated ESR (51 mm/h), and elevated CRP (14 mg/L). Mantoux test was positive (30 mm × 30 mm). Chest X-ray was normal. CT chest revealed few small parenchymal nodules in the right upper lobe. Tissue biopsy from the indurated [Figure 2] and annular plaque [Figure 3] were suggestive of erythema induratum. CBNAAT from the tissue could not detect M. tuberculosis.
Figure 2: Histopathology of indurated plaque showing septal panniculitis (black arrow) and giant cell-rich granuloma with lobular panniculitis (blue arrow) (stain H and E, 40×). Inset on right side showing marked area of vasculitis (blue arrow) (H and E, 400×)

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Figure 3: Histopathology of annular plaque showing lobular panniculitis (H and E, 100×)

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Based on the above findings, the patient was started on standard anti-tubercular therapy (ATT). Within 1 week of initiation of ATT, significant improvement was noted. The erythema decreased over the indurated plaque and the new erythematous annular lesions started to resolve [Figure 1]. Patient was followed up for 1 month with persistent improvement after which she lost to follow up.

The morphological presentation was interesting in this case, with the presence of annular plaques and non-ulcerating nodules, which were present on the anteromedial aspect of the right lower leg and calf, respectively. There are very few cases of EIB presenting as annular plaques.[3] Nodules generally ulcerate in EIB, but in this case, the nodules did not ulcerate. EIB lesions appear mostly as a granulomatous lobular panniculitis on histopathology.[4] However, in this case, the histopathology showed septal and focal lobular panniculitis. Early response to ATT was seen in this case within 1 week of initiating ATT, whereas most studies showed response in 3–4 weeks after starting ATT.[1],[5]

   Conclusion Top

This case is being presented to emphasize that there can be unusual presentations of EIB and its early suspicion can help to find the underlying foci of tuberculosis. Therefore, it is of paramount importance to conduct a detailed search for the foci of tuberculosis in highly endemic countries such as India.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

   References Top

Sharon V, Goodarzi H, Chambers CJ, Fung MA, Armstrong AW. Erythema induratum of Bazin. Dermatol Online J 2010;16:1.  Back to cited text no. 1
Varshney A, Goyal T. Incidence of various clinico-morphological variants of cutaneous tuberculosis and HIV concurrence: A study from the Indian subcontinent. Ann of Saudi Med 2011;31:134-9.  Back to cited text no. 2
Aruna C, Senthil AL, Sridevi K, Swapna K, Ramamurthy DV. A clinicoepidemiological study of cutaneous tuberculosis in a tertiary care teaching hospital in Andhra Pradesh, India. Int J Res Dermatol 2017;3:88-93.  Back to cited text no. 3
Requena L, Yus ES. Panniculitis. part II. mostly lobular panniculitis. J Am Acad Dermatol 2001;45:325-64.  Back to cited text no. 4
Ribeiro R, Patrício C, da Silva FP, Silva PE. Erythema induratum of Bazin and Ponçet's arthropathy as epiphenomena of hepatic tuberculosis. Case Rep 2016:bcr2015213585.  Back to cited text no. 5


  [Figure 1], [Figure 2], [Figure 3]


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