Indian Journal of Dermatology
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Year : 2022  |  Volume : 67  |  Issue : 2  |  Page : 204

Effect of a precision cryotherapy device with temperature adjustability on pigmentation

1 From the Department of Immunology, School of Medicine, Kyungpook National University; BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University, Daegu, Korea
2 Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea
3 Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea

Correspondence Address:
Gun-Ho Kim
(44919) Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, 50 UNIST, Ulsan
Weon Ju Lee
(41944) Department of Dermatology, Kyungpook National University Hospital, 130 Dongduk-ro, Jung-gu, Daegu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijd.ijd_755_21

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Background: Pigmentary skin disorders impair the quality of life, leading to the development of therapeutic modalities. However, these treatments should focus more on effectiveness and safety. Aims and Objectives: To evaluate the effect of a temperature-adjustable cryotherapy device on the expression of pigmentation-related biomarkers. Methods and Results: A temperature- and time-adjustable cryotherapy device was employed to improve 200 mJ UVB-induced pigmentation on mice at −5°C (for 5, 10 or 20 s), 0°C (for 5, 10 or 20 s), 5°C (for 5, 10 or 20 s), or 10°C (for 5, 10 or 20 s). Expression of pigmentation-related biomarkers, such as tyrosinase, c-kit, melanocortin 1 receptor and microphthalmia-associated transcription factor before and after treatment with the cryotherapy device was investigated with real-time polymerase chain reaction and immunohistochemistry. Results: Expression of pigmentation-related biomarkers was decreased after the treatment of the temperature-adjustable cryotherapy device. Gene expression of the pigmentation-related biomarkers was decreased under the above conditions with some exception. Protein expression of the pigmentation-related biomarkers showed decreased tendency under the conditions with some exceptions. Conclusion: The temperature-adjustable cryotherapy device used in this study reduced the expression of pigmentation-related biomarkers on mice and may be used to treat patients with skin pigmentation.

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