Indian Journal of Dermatology
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Year : 2022  |  Volume : 67  |  Issue : 3  |  Page : 314

Migratory panniculitis with autoimmune cholangitis and pancreatitis (IgG4-Related Disease): A rare presentation

1 Consultant Dermatologist, Jaslok Hospital and Research Centre, Mumbai, India
2 Gastroenterologist, Mumbai, India
3 Research Assistant, Dr Skin Pimples Pvt. Ltd., Mumbai, India
4 Consultant Dermatologist and Epidemiologist, Mumbai, Maharashtra, India

Correspondence Address:
Ram H Malkani
Consultant Dermatologist, Jaslok Hospital and Research Centre, Room No. 200, Dr. G Deshmukh Marg, Mumbai, Maharashtra - 400 026
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijd.IJD_373_20

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A 30-year-old woman presented with an acute-onset high-grade fever (103°F), multiple episodes of throbbing abdominal pain in the right quadrant, and pustular red lesions on the left leg. The radiological findings were suggestive of autoimmune cholangitis and pancreatitis. The skin lesions recurred on different portions of the body, and histopathological findings showed lobular and septal lymphohistiocytic infiltrate without vasculitis. The epidermis had focal ulcerations, and the dermis showed the presence of subcutaneous fat and an infiltrate of lymphocytes, histiocytes, and neutrophils (described as lobular and septal panniculitis without vasculitis). Based on the clinical and histopathological features, a diagnosis of migratory panniculitis was made. The patient was managed with analgesics, antibiotics, and a long course of steroids; the patient responded well to these medications. To the best of our knowledge, this is one of the first case reports of migratory panniculitis associated with IgG4-related disease. Patients with migratory panniculitis should be investigated for the presence of IgG4-related autoimmune disease. However, steroids remain the drug of choice when these conditions occur together.

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