Indian Journal of Dermatology
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Year : 2022  |  Volume : 67  |  Issue : 5  |  Page : 512-517

Serum soluble intercellular adhesion molecule-1 (sICAM-1): A novel potential biomarker in severe acne vulgaris

1 Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Egypt
2 Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Egypt
3 Department of Laboratory Medicine, Mansoura Fever Hospital, Ministry of Health, Egypt
4 Department of Dermatology, Mansoura Dermatology and Leprosy Hospital, Mansoura, Ministry of Health, Egypt

Correspondence Address:
Amany Ibrahim Mustafa
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University - 13511
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijd.ijd_387_21

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Background: Acne vulgaris (AV) is a chronic inflammatory disorder. Intercellular adhesion molecule-1 (ICAM-1) is a vital adhesion molecule mediating cellular adhesion during the inflammatory process. Aims and Objectives: To evaluate serum soluble intercellular adhesion molecule-1 (sICAM-1) level in AV patients as an attempt to elucidate its role in acne pathogenesis and to relate with studied clinical parameters. Materials and Methods: Serum sICAM-1 level was measured using ELISA technique in 60 patients and 60 controls. Results: Serum sICAM-1 level was significantly elevated in studied patients than controls (P < 0.001). Additionally, its level increased significantly with increased acne severity (P < 0.001) but not in patients with post acne scars (P > 0.05). Conclusion: Serum sICAM-1 could be a marker for acne etiopathogenesis. Furthermore, it might be considered as a predictor for disease severity.

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