Indian Journal of Dermatology
  Publication of IADVL, WB
  Official organ of AADV
Indexed with Science Citation Index (E) , Web of Science and PubMed
 
Users online: 4364  
Home About  Editorial Board  Current Issue Archives Online Early Coming Soon Guidelines Subscriptions  e-Alerts    Login  
    Small font sizeDefault font sizeIncrease font size Print this page Email this page


 
Table of Contents 
E-IJD® - CORRESPONDENCE
Year : 2022  |  Volume : 67  |  Issue : 5  |  Page : 628
The importance of screening for inflammatory bowel disease in patients with psoriasis and psoriatic arthritis


1 Departments of Dermatology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA
2 Department of Dermatology, University of Alabama at Birmingham Hospital, Birmingham, AL, USA

Date of Web Publication29-Dec-2022

Correspondence Address:
Boni E Elewski
Department of Dermatology, University of Alabama at Birmingham Hospital, Birmingham, AL
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijd.ijd_34_22

Rights and Permissions



How to cite this article:
Aldana I, Balakrishnan V, Elewski BE. The importance of screening for inflammatory bowel disease in patients with psoriasis and psoriatic arthritis. Indian J Dermatol 2022;67:628

How to cite this URL:
Aldana I, Balakrishnan V, Elewski BE. The importance of screening for inflammatory bowel disease in patients with psoriasis and psoriatic arthritis. Indian J Dermatol [serial online] 2022 [cited 2023 Feb 7];67:628. Available from: https://www.e-ijd.org/text.asp?2022/67/5/628/366122




Sir,

A strong association between psoriasis (PsO) and inflammatory bowel disease (IBD) has been established in the literature.[1] Not only are the relative risks of developing PsO significantly increased in patients with both Crohn's disease (CD) and ulcerative colitis (UC), but patients with PsO are at increased risk for developing IBD in the future. The coexistence of these diseases in patients has been further corroborated at the genetic level.[2] Despite this established association, there are a paucity of data demonstrating that clinicians regularly screen patients with PsO for IBD.

We herein present a case previously reported in the literature that underlines the importance of screening for IBD in patients with PsO.[3] A 53-year-old male with a history of PsO and psoriatic arthritis (PsA), initially well-controlled with secukinumab (on therapy for one year), was incidentally diagnosed with CD on a routine colonoscopy that was performed as part of his age-appropriate cancer screening – CT enterography demonstrated wall thickening, fatty replacement of the wall, and increased enhancement of the mucosa of the distal terminal ileum. The patient was transitioned to ustekinumab given the risk of CD exacerbation with IL-17 inhibition. Due to ustekinumab treatment failure after one year of therapy, he was subsequently transitioned to guselkumab. A year of treatment with guselkumab resulted in sustained therapeutic response of the patient's PsO/PsA (Psoriasis Area and Severity Index of 0) with incidentally noted radiographic improvement of his CD. Two years later, the patient reported complete endoscopic remission of his CD and remained asymptomatic clinically with regards to CD. His colonoscopy in August 2020 demonstrated no stigmata of recent bleeding in previously present erosions in the ileum and normally appearing cecum, ascending colon, transverse colon, and descending colon.

This case underlines the importance of screening patients with PsO/PsA for IBD. Feldman et al.[4] demonstrated that patients PsO reported an increased prevalence of Gastro-intestinal (GI) symptoms as compared to non-PsO controls (belly pain, feeling bloated, unintentional weight loss, blood in the stool, mucus in the stool, and diarrhea), and these symptoms were reported with increased frequency in patients with more severe PsO and concomitant PsA. Our patient was asymptomatic from a GI perspective and his CD was found incidentally. This case in conjunction with the epidemiologic and genetic data demonstrating the coexistence of PsO and IBD suggests that patients with PsO who are asymptomatic from a GI perspective should still be screened for IBD. Although the Joint American Academy of Dermatology–National Psoriasis Foundation (AAD-NPD) guidelines frequently refer to IBD in the context of considering various biologic therapeutics, screening all patients with PsO is not explicitly recommended.[5] We propose that inquiring about abdominal symptoms commonly encountered in patients with IBD should be routinely undertaken in all patients who are being treated for PsO/PsA, regardless of the severity of their skin and joint disease.[6]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Fu Y, Lee CH, Chi CC. Association of psoriasis with inflammatory bowel disease: A systematic review and meta-analysis. JAMA Dermatol 2018;154:1417-23.  Back to cited text no. 1
    
2.
Vlachos C, Gaitanis G, Katsanos KH, Christodoulou DK, Tsianos E, Bassukas ID. Psoriasis and inflammatory bowel disease: Links and risks. Psoriasis (Auckl) 2016;6:73-92.  Back to cited text no. 2
    
3.
Shaw CA, Kole LC, Elewski BE. Association of psoriasis/psoriatic arthritis with inflammatory bowel disease influences management strategy. J Eur Acad Dermatol Venereol 2019;33:e431-2.  Back to cited text no. 3
    
4.
Feldman SR, Srivastava B, Abell J, Hoops T, Fakharzadeh S, Chakravarty S, et al. Gastrointestinal signs and symptoms related to inflammatory bowel disease in patients with moderate-to-severe psoriasis. J Drugs Dermatol 2018;17:1298-308.  Back to cited text no. 4
    
5.
Menter A, Strober BE, Kaplan DH, Kivelevitch D, Prater EF, Stoff B, et al. Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics. J Am Acad Dermatol 2019;80:1029-72.  Back to cited text no. 5
    
6.
Berman HS, Villa NM, Shi VY, Hsiao JL. Guselkumab in the treatment of concomitant hidradenitis suppurativa, psoriasis, and Crohn's disease. J Dermatolog Treat 2021;32:261-3.  Back to cited text no. 6
    




 

Top
Print this article  Email this article
 
 
  Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (169 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    References

 Article Access Statistics
    Viewed376    
    Printed4    
    Emailed0    
    PDF Downloaded10    
    Comments [Add]    

Recommend this journal