Indian Journal of Dermatology

Year
: 1997  |  Volume : 42  |  Issue : 1  |  Page : 1--8

Study Of Topical Anti-Inflammatory Potency And Clinical Efficacy Of Formulations Of Mometasone And Betamethasone By Cutaneous Blood Flow Measurements In Psoriatic Patients Using Laser Doppler Velocimetry


S. V Mulekar1, S. S Mahajani2, P. M Kulhalli3, D. S Bakhle4, S. S Menon5 
1 
2 
3 
4 
5 

Correspondence Address:
S. V Mulekar


Laser Doppier Velocimetry (LDV) was used to measure cutaneous blood flow (CBF) in psoriatic skin lesions to assess the effect of once daily application of Mometasone furoate (MF) in a base claimed to possess a “reservoir” effect, as against Betamethasone-17-valarate (BV) in a conventional cream base, applied twice daily, for 4 weeks. Bilaterally symmetrical active lesions were studied in 10 psoriatics, at baseline and at the end of 2 and 4 weeks’ treatment. The formulations were also evaluated for topical anti-inflammatory potency in terms of their ability to inhibit the Post-Ischaemic-Reactive-Hyperaemic-Response (PIRHR) induced on normal uninvolved skin treated under occlusion. The lesions were also assessed subjectively for clinical Psoriatic Hyperaemia Index (PHI = CBF on lesions/CBF on uninvolved skin: 8.42 + 1.74 & 10.13 + 1.70) correlating with high CPI (9 + 0.50 & 9.1 + 0.51). During treatment with MF or BV, the lesions resolved rapidly, with a concomitant decrease in PHI and CPI (Week 2 : PHI = 3.40 + 0.46 & 5.19 + 1.65, CPI = 4.15 + 0.86& 5.20 + 0.87 and Week 4 : PHI = 1.99 + 0.23 & 2.81 + 0.74 CPI = 2.00 + 0.50 & 2.88 + 0.72 respectively). The two formulations Inhibited PIRHR to same extent (auc/min: Control = 1871 + 399.22, MF = 536.11 + 153.34 & BV = 567.5 + 110.76), indicating equal potency. The results show that pharmaceutical factor such as vehicle can significantly influence the clinical efficacy of corticoids.


How to cite this article:
Mulekar S, Mahajani S, Kulhalli P, Bakhle D, Menon S. Study Of Topical Anti-Inflammatory Potency And Clinical Efficacy Of Formulations Of Mometasone And Betamethasone By Cutaneous Blood Flow Measurements In Psoriatic Patients Using Laser Doppler Velocimetry.Indian J Dermatol 1997;42:1-8


How to cite this URL:
Mulekar S, Mahajani S, Kulhalli P, Bakhle D, Menon S. Study Of Topical Anti-Inflammatory Potency And Clinical Efficacy Of Formulations Of Mometasone And Betamethasone By Cutaneous Blood Flow Measurements In Psoriatic Patients Using Laser Doppler Velocimetry. Indian J Dermatol [serial online] 1997 [cited 2022 Sep 25 ];42:1-8
Available from: https://www.e-ijd.org/article.asp?issn=0019-5154;year=1997;volume=42;issue=1;spage=1;epage=8;aulast=Mulekar;type=0