Indian Journal of Dermatology

Year
: 1998  |  Volume : 43  |  Issue : 4  |  Page : 157--161

A Double Blind Immunohistological Study Of The Effect Of Topical Tretinoin On Photoaged Skin


Sumit Kumar Bose 
 

Correspondence Address:
Sumit Kumar Bose


Fifteen very fair women with mild to moderate photoaging in there 60’s were tested by doubled blind immunohistological study. Tretinoin 0.05% cream applied daily was compared to its vehicle with regards to epidermal, basal, spinous differentiation markers and dendritic cells (Langerhan’s and melariocyte). In comparison with the control skin, tretinoin-treated skin showed the following changes: 1. From atrophy to normalization or hyperplasia of horny and prickle cell layers,2. Granular layer was normal to hypertrophied, 3. Basal cells were well-stained and thicker, 4. Basement membrane was thicker to normal in appearance and 5. Dendritic cells were increased in number (Langerhan’s). These results demonstrated a decelerating effect of tretinoin on the time clock of photoaging.


How to cite this article:
Bose S. A Double Blind Immunohistological Study Of The Effect Of Topical Tretinoin On Photoaged Skin.Indian J Dermatol 1998;43:157-161


How to cite this URL:
Bose S. A Double Blind Immunohistological Study Of The Effect Of Topical Tretinoin On Photoaged Skin. Indian J Dermatol [serial online] 1998 [cited 2022 May 19 ];43:157-161
Available from: https://www.e-ijd.org/article.asp?issn=0019-5154;year=1998;volume=43;issue=4;spage=157;epage=161;aulast=Bose;type=0