Indian Journal of Dermatology
CORRESPONDENCE
Year
: 2009  |  Volume : 54  |  Issue : 1  |  Page : 88--89

The efficacy of topical diphencyprone in the treatment of alopecia areata


Akhyani Maryam, Seirafi Hassan, Farnaghi Farshad, Banan Parastoo, Lajevardi Vahide 
 Department of Dermatology, Razi Hospital, Tehran University of Medical, Sciences, Tehran, Iran

Correspondence Address:
Lajevardi Vahide
Department of Dermatology, Razi Hospital, Tehran University of Medical, Sciences, Tehran
Iran




How to cite this article:
Maryam A, Hassan S, Farshad F, Parastoo B, Vahide L. The efficacy of topical diphencyprone in the treatment of alopecia areata.Indian J Dermatol 2009;54:88-89


How to cite this URL:
Maryam A, Hassan S, Farshad F, Parastoo B, Vahide L. The efficacy of topical diphencyprone in the treatment of alopecia areata. Indian J Dermatol [serial online] 2009 [cited 2022 Oct 3 ];54:88-89
Available from: https://www.e-ijd.org/text.asp?2009/54/1/88/49001


Full Text

Sir,

In a retrospective study, 54 patients (38 females and 16 males) with chronic extensive alopecia areata, who had used diphencyprone (DPCP) for more than 1.5 years, between January of 2001 and December of 2005, were studied. The extent of hair loss was severe (>75%), moderate (26-75%), and mild ( P = 0.017).

There was no relationship between response to treatment and sex, onset of disease, nail involvement, atopy, extent of hair loss, and family history of alopecia areata.

During the treatment, 33% of the patients experienced relapse. Continuation of the DPCP therapy caused hair re-growth in 21 of them. Adverse effects included contact dermatitis on the face or neck (five of 54), hyperpigmentation (four of 54) and occipital lymphadenopathy (one of 54).

In this study, the response to the treatment in 55.5% of the patients was appropriate. In other reports, however, the percentage of success varied greatly from four to 85%. [1] The changes in response rates may be due to the number of patients in trials, the type, duration and severity of the alopecia areata, and different methods of assessing clinical efficacy.

In addition, in our study, duration of disease was the only predictor for response rate. The presence of nail changes, a personal history of atopy, long duration of alopecia before treatment, baseline extent of alopecia, age at disease onset and duration of treatment have been considered as prognostic factors in other studies. [2],[3],[4]

It seems that the topical DPCP in the treatment of severe alopecia areata is effective, but with a slightly high relapse rate during treatment. Duration of the disease, less than 10 years, is a main predictor for this response rate.

References

1Happle R. Diphencyprone for the treatment of alopecia areata: More data and new aspects. Arch Dermatol 2002;138:112-3.
2Firooz A, Bouzari N, Mojtahed F, Pazoki-Toroudi H, Nassiri-Kashani M, Davoudi M, et al . Topical immunotherapy with diphencyprone in the treatment of extensive and/or long-lasting alopecia areata. J Eur Acad Dermatol Venereol 2005;19:393-4.
3Galadari I, Rubaie S, Alkaabi J, Galadari H. Diphenylcyclopropenone (diphencyprone, DPCP) in the treatment of chronic severe alopecia areata (AA). Eur Ann Allergy Clin Immunol 2003;35:397-401.
4Singh G, Okade R, Naik C, Dayanand CD. Diphencyprone immunotherapy in ophiasis. Indian J Dermatol Venerol Leprol 2007;73:432-3.