Indian Journal of Dermatology
: 2011  |  Volume : 56  |  Issue : 3  |  Page : 318--320

Folliculitis et perifolliculitis capitis abscedens et suffodiens controlled with a combination therapy: Systemic antibiosis (Metronidazole Plus Clindamycin), dermatosurgical approach, and high-dose isotretinoin

Georgi Tchernev 
 Department of Dermatology and Venerology, Trakian University, Medical Faculty, Stara Zagora, Bulgaria

Correspondence Address:
Georgi Tchernev
Associated Professor in Dermatology and Venerology, Department of Dermatology and Venerology, Trakian University, Medical Faculty, Armeiska street 11, Stara Zagora


Folliculitis et perifolliculitis capitis abscedens et suffodiens is a rare disease of unknown etiology. It is a suppurative process that involves the scalp, eventually resulting in extensive scarring and irreversible alopecia. The condition is also known as �SQ�acne necrotica miliaris�SQ� or �SQ�Proprionibacterium�SQ� folliculitis. Most often the disease affects men of African-American or African-Caribbean descent between 20 and 40 years of age. The clinical picture is determined by fluctuating painful fistule-forming conglomerates of abscesses in the region of the occipital scalp. The cause of scalp folliculitis is not well understood. It is generally considered to be an inflammatory reaction to components of the hair follicle, particularly the micro-organisms. These include: bacteria (especially Propionibacterium acnes, but in severe cases, also Staphylococcus aureus), Yeasts (Malassezia species) and mites (Demodex folliculorum). The initial histopathologic finding is an exclusively neutrophilic infiltration followed by a granulomatous infiltrate. The treatment of the disease is usually difficult and often disappointing. Successful treatment with isotretinoin 1 mg/kg body mass could be achieved only after regular systematic administration in the course of 3-4 months. Here we describe a patient with eruptive purulent form of the disease, which has been controlled with combination therapy: systemic antibiosis with metronidazole and clindamycin, dermatosurgical removal of single nodular formations, and isotretinoin 1 mg/kg body mass for 3-5 months.

How to cite this article:
Tchernev G. Folliculitis et perifolliculitis capitis abscedens et suffodiens controlled with a combination therapy: Systemic antibiosis (Metronidazole Plus Clindamycin), dermatosurgical approach, and high-dose isotretinoin.Indian J Dermatol 2011;56:318-320

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Tchernev G. Folliculitis et perifolliculitis capitis abscedens et suffodiens controlled with a combination therapy: Systemic antibiosis (Metronidazole Plus Clindamycin), dermatosurgical approach, and high-dose isotretinoin. Indian J Dermatol [serial online] 2011 [cited 2023 Sep 21 ];56:318-320
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The folliculitis et perifolliculitis capitis abscedens et suffoidens disease was described by Spritzer for the first time in 1903, and its denomination was given later by Hoffmann in 1908. [1],[2] It is clinically characterized by the formation of pimples, nodules, and abscesses communicating between each other and which, after the healing phase, remain in the form of atrophic, hypertrophic, and keloidal scars. The most frequently affected areas are the vertex and the occipital part of the scalp. The association with Hidradenitis suppurativa and Acne conglobata supposes a common pathogenic mechanism, originally based on the follicular retention. In 30% of the cases, combinations of acne vulgaris have been described. This disease has been considered to be a part of follicular occlusive triad or tetrad: A. conglobata, h. suppurativa, and pilonidal cysts. [3] Common anatomic and clinical alterations arising after the follicular occlusion are the formation of different sizes of comedones and abscesses, connected by communicating channels and sinuses. [1],[2],[3]

Secondary formations of squamous cell carcinomas on lesions affected by this disease have been already described. Metastasizing planocellular tumors have also been reported. [4]

The main reason is considered to be the disordered keratinization and further occlusion and accumulation of keratin at the hair follicle. After a dilatation followed by rupture, not only a granulomatous inflammatory process accompanied by the attraction of gigantic cells, partially phagocyting the keratin masses are induced in the hair follicle, but also an inflammatory bacterial process derived from a superinfection, most frequently caused by Staphylococcus aureus and Staphylococcus epidermidis, which are considered to be the main factors in the chemotaxis of neutrophils. After an adequate therapy is given, an irreversible alopecia remains, due to the disordered structure of the hair follicle by the infiltration of neutrophils and giant inflammatory cells.

It is of histologic and immunohistologic importance to exclude the folliculotropic form of mycosis fungoides. [5]

Consequently, regular examinations of the patient are recommended, including the dermatologic and general status, blood picture, histologic and sometimes immunohistologic analyses.

 Case Report

This case concerns the patient P.G., 30 years of age, nonsmoker, who passed through the polyclinic. His complaints had begun 7 months earlier, when lesions that were painful and fluctuating between each other had appeared in the subcutaneous zone of the occipital skull area. The patient reported that he was also losing his hair at the places, where the nodules appeared. The ambulatory biopsy showed destructing granulation and abscessing inflammation with partially perifollicular nature. The ambulatorily applied therapy by cefuroxime and metronidazole gave no therapeutic results.

In the occipitoparietal and also in the parietal area, nodular confluent conglomerated with exophytic growth trending to form fistula were found [Figure 1]a. The conglomerates were not stuck to the aponeurosis and, if pressed, a purulent secretion was spread, not only from the close vicinity to the pressed area, but also from distant areas, which clearly proved the presence of fistulae and sinuses, communicating between each other. Hairless areas were noticed at the sectors of the head affected by the nodules. Exaggerated and painful lymphatic nodes supraclavicularly, left, were found. The patient's general status was good.{Figure 1}

Laboratory and microbiology findings

The biochemical tests held and the peripheral blood picture showed quite normal results, except for the neutrophils (76.6%) and lymphocytes (13.5%).

The macrobiological smear after contests on the nodular formation parietally and aspiration of secretion showed a minimal growth of Candida albicans and S. aureus; hair culture: minimal growth of C. albicans.

Echography of the occipitoparietal and parietal skull part in the zone of the affected areas: Multiple capsulated structures showing no echogenicity, possible presence of cystic formations.

Cutaneous and subcutaneous pseudocystic sectors or abscesses were bilaterally and parietally detected in magnetic resonance tomography of the head. Reactive raise and dissemination of tabula externa, parietally, right. Due to the presence of a minimal perilesional edema, significant abscessing was not very probable. Superinfection of single nodular components was not excludable.

Histopathology findings

Dermis with hair follicles and dilated vessels were seen on the foreground. A dense, mixed inflammatory infiltrate consisting of lymphocytes, plasmacellular infiltrates, neutrophils, and single macrophages was found. Epidermal edema: Multiple giant cells arranged side by side, follicular and perifollicular mixed inflammatory infiltrates. No cystic wall was present.


Granulomatous dermatitis with mixed inflammatory infiltrate.

Treatment and outcome

Systemic therapy by metronidazole 400 mg twice a day in combination with clindamycin, 600 mg 3 times daily, intravenously, for 2 weeks was applied [Figure 1]b.

Partial incision of nodular lesions from the occipital and occipitoparietal vertex area was performed. A tangential removal of the superior dermal and epidermal part, also of the pseudocystic-structured nodular formation and removal of the pseudocystic content by simple abrasion with scalpel were made. The defect was covered by a skin sector fixed by a primary stitching. Centesis and evacuation of significant quantities of dense secretion and taking of microbiological smears was done.

After that a systemic treatment by isotretinoin 1 mg/kg of body weight, per os, was applied.

The treatment continued for 3.5 months and a significant improvement of the clinical findings was noticed.


Initially we thought that the patient was suffering from Acne nodulocystica, because of the anamnesis revealing serious acne in the past, as well as because the nodular, fistula-making nature of the lesions. The microscopic analysis showed perifollicular hyperkeratosis, accumulation of keratotic materials in the ostium of the follicles, strongly expressed neutrophilic infiltrate combined with macrophages, giant cells, histiocytes, and lymphocytes in the area of the papillary and reticular dermal layer of the skin. The histologic diagnosis was: "Granulomatous dermatitis with mixed inflammatory infiltrate." No cystic formations could be evaluated by magnetic resonance tomography of the head and histopathologically.

The untypical manifestation of tinea capitis has been excluded by microbiological and histologic examination for fungal infection.

Due to the resistance of the nodules and their difficult susceptibility to the aforesaid therapy (dermatosurgical approach and systemic antibiotic treatment), a systematic treatment by isotretinoin 1 mg/kg of body weight, per os, was applied. After this treatment, which continued for 3.5 months, and further reduction of the dose to 0.5 mg/kg of body weight because of the appearance of epistaxis and dryness in the ocular and buccal mucosae, a significant improvement of the clinical findings was noticed [Figure 2].{Figure 2}

The therapy of this disease is difficult and leads to unsatisfactory results. [6] Different therapeutic approaches, such as monotherapy by isotretinoin, as well as isotretinoin combined with glycocorticoids, antibiotics, and zinc remedies have been already described. [7],[8],[9],[10],[11] Laser epilation, X-ray epilation, injection of glycocorticoids into the skin lesions and surgical incision have been used as supplementary methods. [12],[13],[14]

In the case of our patient, the antibiotic therapy that was initially given in combination with local disinfectants for 2 weeks, did not lead to the desirable results. The complete surgical removal of the nodules was not possible. The next systemic therapy using isotretinoin for 3-4 months gave good results.


Folliculitis et perifolliculitis capitis abscendens et suffoidens is difficult to treat, and its early diagnostics and its systemic treatment by isotretinoin lead to significant improvement of the clinical picture due to the reduction in the nodule growth. Because of the existent possibility for malignant transformation, long observation and, if necessary, controlling histologic analysis are recommended.


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