Indian Journal of Dermatology
ORIGINAL ARTICLE
Year
: 2020  |  Volume : 65  |  Issue : 2  |  Page : 112--117

Association of acanthosis nigricans and acrochordon with insulin resistance: A cross-sectional hospital-based study from North India


Satyendra K Singh1, Neeraj K Agrawal2, Ajay K Vishwakarma1 
1 Department of Dermatology and Venereology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
2 Department of Endocrinology and Metabolism, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Correspondence Address:
Satyendra K Singh
Department of Dermatology and Venereology, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005,Uttar Pradesh
India

Background: Insulin resistance (IR) is a pre-diabetic condition and has been reported in patients with acanthosis nigricans (AN) and acrochordon. AN and acrochordon are claimed to be cutaneous markers of IR. Aim: The purpose of this paper was to study the association of AN and acrochordon with IR. Methods: It was a cross-sectional hospital-based study. Both groups were assessed for IR by using homeostatic model assessment of insulin resistance (HOMA-IR) formula. Results: A total of 70 cases and an equal number of controls were studied. IR was observed more in cases (41.4%) compared to controls (17.1%) (P < 0.01). Mean HOMA-IR value was also significantly higher in cases (4.32 ± 4.44) compared to controls (2.27 ± 0.90) (P < 0.05). Limitations: Low number of cases and controls were taken in the study. Association with hyperlipidemia and metabolic syndrome was not elicited. Conclusions: AN and acrochordons were found to be associated with IR.


How to cite this article:
Singh SK, Agrawal NK, Vishwakarma AK. Association of acanthosis nigricans and acrochordon with insulin resistance: A cross-sectional hospital-based study from North India.Indian J Dermatol 2020;65:112-117


How to cite this URL:
Singh SK, Agrawal NK, Vishwakarma AK. Association of acanthosis nigricans and acrochordon with insulin resistance: A cross-sectional hospital-based study from North India. Indian J Dermatol [serial online] 2020 [cited 2022 May 21 ];65:112-117
Available from: https://www.e-ijd.org/article.asp?issn=0019-5154;year=2020;volume=65;issue=2;spage=112;epage=117;aulast=Singh;type=0