Indian Journal of Dermatology
ORIGINAL ARTICLE
Year
: 2022  |  Volume : 67  |  Issue : 2  |  Page : 109--114

Serum leptin and adiponectin: Indicators of cardiovascular disease secondary to psoriasis


Haoxiang Yan1, Bei Yu1, Jinlan Tian2, Dengmei Xia1, Yang Xu1, Changqiang Li1 
1 From the Department of Dermatology, The Affiliated Hospital of Southwest Medical University, China
2 Department of Dermatology, Suining Central Hospital, China

Correspondence Address:
Changqiang Li
Department of Dermatology, The Affiliated Hospital of Southwest Medical University, Luzhou - 646 000
China

Background: To explore the role and clinical significance of serum adiponectin and leptin levels in patients with psoriasis accompanied by atherosclerosis. Methods: Eighty patients diagnosed with psoriasis in our dermatology department and 40 healthy people in our physical examination centre were included as the study group and control group, respectively. All the included patients underwent fasting blood and serum tests. Levels of adiponectin, leptin, and the blood lipid content; colour Doppler ultrasonography of both common carotid arteries, internal carotid and external carotid arteries; and intimal-medial thickness (IMT) and carotid plaque were evaluated. Results: In the study group, the leptin level increased, and the serum adiponectin level decreased; these levels were statistically significantly different compared with those in the control group (t = 6.774, P < 0.001 and t = –3.511, P < 0.05, respectively). IMT was negatively correlated with adiponectin levels (r = –0.378, P < 0.001) and positively correlated with leptin levels (r = 0.581, P < 0.001). Conclusions: The imbalanced expression of serum and adiponectin levels will aggravate psoriasis and promote the occurrence of atherosclerosis. Serum levels can be used to assess the disease severity, detect vascular lesions early, and prevent the development of psoriasis to cardiovascular disease.


How to cite this article:
Yan H, Yu B, Tian J, Xia D, Xu Y, Li C. Serum leptin and adiponectin: Indicators of cardiovascular disease secondary to psoriasis.Indian J Dermatol 2022;67:109-114


How to cite this URL:
Yan H, Yu B, Tian J, Xia D, Xu Y, Li C. Serum leptin and adiponectin: Indicators of cardiovascular disease secondary to psoriasis. Indian J Dermatol [serial online] 2022 [cited 2022 Aug 17 ];67:109-114
Available from: https://www.e-ijd.org/article.asp?issn=0019-5154;year=2022;volume=67;issue=2;spage=109;epage=114;aulast=Yan;type=0