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Figure 3: (a) Normal urothelium replaced by large cells with eosinophilic cytoplasm and peripherally pushed nuclei giving a signet-ring appearance seen. Inset shows a lymphovascular emboli in the muscularis (H and E, ×400). Positive immunostains for (b) GATA3, (c) CK20, (d) BerEP4, (e) CK, and (f) E-cadherin in the urinary bladder wall (×400)

Figure 3: (a) Normal urothelium replaced by large cells with eosinophilic cytoplasm and peripherally pushed nuclei giving a signet-ring appearance seen. Inset shows a lymphovascular emboli in the muscularis (H and E, ×400). Positive immunostains for (b) GATA3, (c) CK20, (d) BerEP4, (e) CK, and (f) E-cadherin in the urinary bladder wall (×400)